The Single-cell Analytics Innovation Laboratory (SAIL) is a leading platform and innovation hub for cutting-edge molecular profiling and data analysis, serving the broader Memorial Sloan Kettering community.
SAIL is embedded within the Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center (GMTEC) and is available to all basic and translational research laboratories at MSKCC. We implement, test and refine single-cell omic and spatial transcriptomic technologies and protocols for high-resolution profiling of a wide range of tissues, from animal and cell-based systems to diverse tumor types. These approaches are providing unparalleled insights into basic biology as well as cancer-related questions around immunity, tumor plasticity and metastasis, regeneration, wound healing and immunotherapy.
Ronan Chaligné was appointed as the Head of SAIL in 2020 and directs its experimental side, and Roshan Sharma leads the computational team. Dr. Chaligné is an expert in single-cell technologies and their application to biological questions and has developed methods to profile multiple data modalities from the same cell. Dr. Sharma has expertise in developing novel computational methods and adapting existing statistical tools to process and analyze single-cell data with the goal of extracting biological insights. Dana Pe’er, Chair of the Computational and Systems Biology Program in the Sloan Kettering Institute, is the Scientific Director of SAIL. Dr. Pe’er has pioneered a number of foundational analytical concepts and algorithms in the single-cell field.
Our mission is to assimilate emerging technologies in the rapidly advancing fields of single-cell sequencing and imaging-based profiling and provide robust analytical solutions.
Cell. 2025 Mar 5 : S0092-8674(25)00194-1. doi: 10.1016/j.cell.2025.02.009.
Yi Fu, Max Land, Tamar Kavlashvili, Ruobing Cui, Minsoo Kim, Emily DeBitetto, Toby Lieber, Keun Woo Ryu, Elim Choi, Ignas Masilionis, Rahul Saha, Meril Takizawa, Daphne Baker, Marco Tigano, Caleb A Lareau, Ed Reznik, Roshan Sharma, Ronan Chaligne, Craig B Thompson, Dana Pe'er, Agnel Sfeir
Nature Genetics. 2025 Jan 8 Volume 57, pages 451–460
Tsion Abay, Robert R. Stickels, Meril T. Takizawa, Benan N. Nalbant, Yu-Hsin Hsieh, Sidney Hwang, Catherine Snopkowski, Kenny Kwok Hei Yu, Zaki Abou-Mrad, Viviane Tabar, Brooke E. Howitt, Leif S. Ludwig, Ronan Chaligné, Ansuman T. Satpathy & Caleb A. Lareau
Nature. 2025 Jan 23 Volume 637, pages 947–954
Andrew Moorman, Elizabeth K. Benitez, Francesco Cambulli, Qingwen Jiang, Ahmed Mahmoud, Melissa Lumish, Saskia Hartner, Sasha Balkaran, Jonathan Bermeo, Simran Asawa, Canan Firat, Asha Saxena, Fan Wu, Anisha Luthra, Cassandra Burdziak, Yubin Xie, Valeria Sgambati, Kathleen Luckett, Yanyun Li, Zhifan Yi, Ignas Masilionis, Kevin Soares, Emmanouil Pappou, Rona Yaeger, T. Peter Kingham, William Jarnagin, Philip B. Paty, Martin R. Weiser, Linas Mazutis, Michael D’Angelica, Jinru Shia, Julio Garcia-Aguilar, Tal Nawy, Travis J. Hollmann, Ronan Chaligné, Francisco Sanchez-Vega, Roshan Sharma, Dana Pe’er, Karuna Ganesh
We are (almost) always seeking energetic and passionate individuals to join our team. We are passionate about single-cell methods development in the wet and dry lab. If you are naturally curious about biology, want to invent new technologies, and enjoy working in a creative and dynamic environment, we would love to work with you!
